Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance

Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance

Although anti-tumor activities of type I interferons (IFNs) have been recognized for decades, the molecular mechanisms contributing to clinical response remain poorly understood. The complex functions of these pleiotropic cytokines include stimulation of innate and adaptive immune responses against...

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Bibliographic Details
Main Authors: Jennifer L. Green, Robin E. Osterhout, Amy L. Klova, Carsten Merkwirth, Scott R.P. McDonnell, Reza Beheshti Zavareh, Bryan C. Fuchs, Adeela Kamal, Jørn S. Jakobsen
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
type I interferon
bladder cancer
constitutive ISG
IFN resistance
IFN biomarker
nadofaragene firadenovec
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001558

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http://www.sciencedirect.com/science/article/pii/S2372770521001558

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