Inhibition of TRPM7 suppresses migration and invasion of prostate cancer cells via inactivation of ERK1/2, Src and Akt pathway signaling

Inhibition of TRPM7 suppresses migration and invasion of prostate cancer cells via inactivation of ERK1/2, Src and Akt pathway signaling

Background: Prostate cancer is the second most common cause of cancer related death in males worldwide. Most patients show no response to androgen deprivation therapy in case of recurrence and proceed to advanced stage with metastasis. TRPM7 is reported to be upregulated in diverse types of tumors....

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Main Authors: Eun Hye Lee, Jun Nyung Lee, Song Park, So Young Chun, Bo Hyun Yoon, Jae-Wook Chung, Seock Hwan Choi, Bum Soo Kim, Hyun Tae Kim, Tae Hwan Kim, Eun Sang Yoo, Sangkyu Lee, Jae Young Choi, Tae Gyun Kwon, Yun-Sok Ha
Format: Article
Language:English
Published: MRE Press 2022-06-01
Series:Journal of Men's Health
Subjects:
prostate cancer therapy
transient receptor potential cation channel-subfamily m member 7
migration ability
cell proliferation
src signaling
Online Access:https://www.imrpress.com/journal/JOMH/18/7/10.31083/j.jomh1807144

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https://www.imrpress.com/journal/JOMH/18/7/10.31083/j.jomh1807144

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