Optimization of duplex stability and terminal asymmetry for shRNA design.

Optimization of duplex stability and terminal asymmetry for shRNA design.

Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in the results and the requirement for significant computational resources. Here we...

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Autori principali: Olga V Matveeva, Yibin Kang, Alexey N Spiridonov, Pål Saetrom, Vladimir A Nemtsov, Aleksey Y Ogurtsov, Yury D Nechipurenko, Svetlana A Shabalina
Natura: Articolo
Lingua:English
Pubblicazione: Public Library of Science (PLoS) 2010-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC2857877?pdf=render

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http://europepmc.org/articles/PMC2857877?pdf=render

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