TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter

TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter

Abstract Background As a lipid metabolic disorder, non-alcoholic fatty liver disease (NAFLD) is an important cause of cirrhosis and hepatocellular carcinoma, with no effective drug up to date. Previous studies have demonstrated increased methylation levels of key genes in NAFLD, suggesting that hydr...

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Bibliographic Details
Main Authors: Jingjie Wang, Yitong Zhang, Qin Zhuo, Yujen Tseng, Jiucun Wang, Yanyun Ma, Jun Zhang, Jie Liu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Nutrition & Metabolism
Subjects:
TET1
NAFLD
PPARα
Fatty acid oxidation
Hydroxymethylation
Online Access:http://link.springer.com/article/10.1186/s12986-020-00466-8

Internet

http://link.springer.com/article/10.1186/s12986-020-00466-8

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