Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model

Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model

Hepatocyte infection by malaria sporozoites is a bottleneck in the life-cycle of Plasmodium spp. including P. falciparum, which causes the most lethal form of malaria. Therefore, developing an effective vaccine capable of inducing the strong humoral and cellular immune responses necessary to block t...

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Bibliographic Details
Main Authors: Mohammad Shahnaij, Mitsuhiro Iyori, Hiroaki Mizukami, Mayu Kajino, Iroha Yamagoshi, Intan Syafira, Yenni Yusuf, Ken Fujiwara, Daisuke S. Yamamoto, Hirotomo Kato, Nobuhiko Ohno, Shigeto Yoshida
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
human adenovirus serotype 5
adeno-assoicated virus
AAV8
Plasmodium falciparum circumsporozoite protein
malaria
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.612910/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.612910/full

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