Identification of an Optimal TLR8 Ligand by Alternating the Position of 2′-O-Ribose Methylation

Identification of an Optimal TLR8 Ligand by Alternating the Position of 2′-O-Ribose Methylation

Recognition of RNA by receptors of the innate immune system is regulated by various posttranslational modifications. Different single 2′-O-ribose (2′-O-) methylations have been shown to convert TLR7/TLR8 ligands into specific TLR8 ligands, so we investigated whether the position of 2′-O-methylation...

Full description

Bibliographic Details
Main Authors: Marina Nicolai, Julia Steinberg, Hannah-Lena Obermann, Francisco Venegas Solis, Eva Bartok, Stefan Bauer, Stephanie Jung
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
TLR7
TLR8
2′-O-ribose-methylation
RNase T2
immune activation
Online Access:https://www.mdpi.com/1422-0067/23/19/11139

Internet

https://www.mdpi.com/1422-0067/23/19/11139

Similar Items