Identification of an Optimal TLR8 Ligand by Alternating the Position of 2′-O-Ribose Methylation
Recognition of RNA by receptors of the innate immune system is regulated by various posttranslational modifications. Different single 2′-O-ribose (2′-O-) methylations have been shown to convert TLR7/TLR8 ligands into specific TLR8 ligands, so we investigated whether the position of 2′-O-methylation...
Main Authors: | Marina Nicolai, Julia Steinberg, Hannah-Lena Obermann, Francisco Venegas Solis, Eva Bartok, Stefan Bauer, Stephanie Jung |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-09-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/19/11139 |
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