CRISPR/dCas9-based metabolic pathway engineering for the systematic optimization of exopolysaccharide biosynthesis in Streptococcus thermophilus

CRISPR/dCas9-based metabolic pathway engineering for the systematic optimization of exopolysaccharide biosynthesis in Streptococcus thermophilus

ABSTRACT: Streptococcus thermophilus is used extensively in the dairy industry and has shown great promise as a chassis cell for the biosynthesis of high-value metabolites. However, metabolic engineering in S. thermophilus lacks effective genetic modification tools to modulate gene expression to rel...

Full description

Bibliographic Details
Main Authors: Linghui Kong, Zhiqiang Xiong, Xin Song, Yongjun Xia, Lianzhong Ai
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Journal of Dairy Science
Subjects:
CRISPR interference
multiplex gene repression
exopolysaccharide biosynthesis
uridine diphosphate glucose sugar metabolism
Streptococcus thermophilus
Online Access:http://www.sciencedirect.com/science/article/pii/S002203022200337X

Internet

http://www.sciencedirect.com/science/article/pii/S002203022200337X

Similar Items