CRISPR/dCas9-based metabolic pathway engineering for the systematic optimization of exopolysaccharide biosynthesis in Streptococcus thermophilus

CRISPR/dCas9-based metabolic pathway engineering for the systematic optimization of exopolysaccharide biosynthesis in Streptococcus thermophilus

ABSTRACT: Streptococcus thermophilus is used extensively in the dairy industry and has shown great promise as a chassis cell for the biosynthesis of high-value metabolites. However, metabolic engineering in S. thermophilus lacks effective genetic modification tools to modulate gene expression to rel...

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Bibliographic Details
Main Authors:	Linghui Kong, Zhiqiang Xiong, Xin Song, Yongjun Xia, Lianzhong Ai
Format:	Article
Language:	English
Published:	Elsevier 2022-08-01
Series:	Journal of Dairy Science
Subjects:	CRISPR interference multiplex gene repression exopolysaccharide biosynthesis uridine diphosphate glucose sugar metabolism Streptococcus thermophilus
Online Access:	http://www.sciencedirect.com/science/article/pii/S002203022200337X

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