Discovery of Nitro-azolo[1,5-<i>a</i>]pyrimidines with Anti-Inflammatory and Protective Activity against LPS-Induced Acute Lung Injury

Discovery of Nitro-azolo[1,5-<i>a</i>]pyrimidines with Anti-Inflammatory and Protective Activity against LPS-Induced Acute Lung Injury

Acute lung injury remains a challenging clinical condition, necessitating the development of novel, safe and efficient treatments. The prevention of macrophage M1-polarization is a viable venue to tackle excessive inflammation. We performed a phenotypic screening campaign to identify azolopyrimidine...

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Bibliographic Details
Main Authors: Alexander Spasov, Vadim Kosolapov, Denis Babkov, Vladlen Klochkov, Elena Sokolova, Mikhail Miroshnikov, Alexander Borisov, Yulia Velikorodnaya, Alexey Smirnov, Konstantin Savateev, Victor Fedotov, Svetlana Kotovskaya, Vladimir Rusinov
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
cytokine
IL-6
inflammation
acute lung injury
macrophage
azolo[1,5-<i>a</i>]pyrimidines
Online Access:https://www.mdpi.com/1424-8247/15/5/537

Internet

https://www.mdpi.com/1424-8247/15/5/537

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