Methadone Requires the Co-Activation of μ-Opioid and Toll-Like-4 Receptors to Produce Extracellular DNA Traps in Bone-Marrow-Derived Mast Cells

Methadone Requires the Co-Activation of μ-Opioid and Toll-Like-4 Receptors to Produce Extracellular DNA Traps in Bone-Marrow-Derived Mast Cells

Methadone is an effective and long-lasting analgesic drug that is also used in medication-assisted treatment for people with opioid use disorders. Although there is evidence that methadone activates μ-opioid and Toll-like-4 receptors (TLR-4s), its effects on distinct immune cells, including mast cel...

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Bibliographic Details
Main Authors: Frida L. Martínez-Cuevas, Silvia L. Cruz, Claudia González-Espinosa
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
methadone
µ-opioid receptors
TLR4 receptors
mast cells
ETosis
mast cell extracellular traps
Online Access:https://www.mdpi.com/1422-0067/25/4/2137

Internet

https://www.mdpi.com/1422-0067/25/4/2137

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