Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer.
Cigarette smoke exposure markedly compromises the ability of the immune system to protect against invading pathogens and tumorigenesis. Nicotine is a psychoactive component of tobacco products that acts as does the natural neurotransmitter, acetylcholine, on nicotinic receptors (nAChRs). Here we dem...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3585320?pdf=render |
| _version_ | 1819238212448550912 |
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| author | Junwei Hao Fu-Dong Shi Mohammed Abdelwahab Samuel X Shi Alain Simard Paul Whiteaker Ronald Lukas Qinghua Zhou |
| author_facet | Junwei Hao Fu-Dong Shi Mohammed Abdelwahab Samuel X Shi Alain Simard Paul Whiteaker Ronald Lukas Qinghua Zhou |
| author_sort | Junwei Hao |
| collection | DOAJ |
| description | Cigarette smoke exposure markedly compromises the ability of the immune system to protect against invading pathogens and tumorigenesis. Nicotine is a psychoactive component of tobacco products that acts as does the natural neurotransmitter, acetylcholine, on nicotinic receptors (nAChRs). Here we demonstrate that natural killer (NK) cells strongly express nAChR β2. Nicotine exposure impairs the ability of NK cells to kill target cells and release cytokines, a process that is largely abrogated by nAChR β2 deficiency. Further, nicotinic suppression of NF-κB-induced transcriptional activity in NK cells is dependent on nAChR β2. This nAChR subtype also plays a large role in the NK cell-mediated control of melanoma lung metastasis, in a murine lung metastasis model exposed to nicotine. Our findings suggest nAChR β2 as a prominent pathway for nicotine induced impairment of NK cell functions which contributes to the occurrence of smoking-related pathologies. |
| first_indexed | 2024-12-23T13:32:38Z |
| format | Article |
| id | doaj.art-3bf36803133245879d5a87042f4b2590 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T13:32:38Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3bf36803133245879d5a87042f4b25902022-12-21T17:45:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5749510.1371/journal.pone.0057495Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer.Junwei HaoFu-Dong ShiMohammed AbdelwahabSamuel X ShiAlain SimardPaul WhiteakerRonald LukasQinghua ZhouCigarette smoke exposure markedly compromises the ability of the immune system to protect against invading pathogens and tumorigenesis. Nicotine is a psychoactive component of tobacco products that acts as does the natural neurotransmitter, acetylcholine, on nicotinic receptors (nAChRs). Here we demonstrate that natural killer (NK) cells strongly express nAChR β2. Nicotine exposure impairs the ability of NK cells to kill target cells and release cytokines, a process that is largely abrogated by nAChR β2 deficiency. Further, nicotinic suppression of NF-κB-induced transcriptional activity in NK cells is dependent on nAChR β2. This nAChR subtype also plays a large role in the NK cell-mediated control of melanoma lung metastasis, in a murine lung metastasis model exposed to nicotine. Our findings suggest nAChR β2 as a prominent pathway for nicotine induced impairment of NK cell functions which contributes to the occurrence of smoking-related pathologies.http://europepmc.org/articles/PMC3585320?pdf=render |
| spellingShingle | Junwei Hao Fu-Dong Shi Mohammed Abdelwahab Samuel X Shi Alain Simard Paul Whiteaker Ronald Lukas Qinghua Zhou Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. PLoS ONE |
| title | Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. |
| title_full | Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. |
| title_fullStr | Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. |
| title_full_unstemmed | Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. |
| title_short | Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. |
| title_sort | nicotinic receptor β2 determines nk cell dependent metastasis in a murine model of metastatic lung cancer |
| url | http://europepmc.org/articles/PMC3585320?pdf=render |
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