Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells

Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells

Transcription of protein coding genes is accompanied by recruitment of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form H3K4me1, H3K4me2 and H3K4me3. Here, we determine the importance of COMPASS in maintaining gene expression across lifespan in budding yeas...

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Bibliographic Details
Main Authors: Cristina Cruz, Monica Della Rosa, Christel Krueger, Qian Gao, Dorottya Horkai, Michelle King, Lucy Field, Jonathan Houseley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
histone
methylation
ageing
COMPASS
gene expression
Online Access:https://elifesciences.org/articles/34081

Internet

https://elifesciences.org/articles/34081

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