Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells
Transcription of protein coding genes is accompanied by recruitment of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form H3K4me1, H3K4me2 and H3K4me3. Here, we determine the importance of COMPASS in maintaining gene expression across lifespan in budding yeas...
Main Authors: | Cristina Cruz, Monica Della Rosa, Christel Krueger, Qian Gao, Dorottya Horkai, Michelle King, Lucy Field, Jonathan Houseley |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/34081 |
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