Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy

Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy

Cluster of differentiation 47 (CD47)/signal regulatory protein alpha (SIRPα) is a negative innate immune checkpoint signaling pathway that restrains immunosurveillance and immune clearance, and thus has aroused wide interest in cancer immunotherapy. Blockade of the CD47/SIRPα signaling pathway shows...

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Bibliographic Details
Main Authors: Bo Huang, Zhaoshi Bai, Xinyue Ye, Chenyu Zhou, Xiaolin Xie, Yuejiao Zhong, Kejiang Lin, Lingman Ma
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Immunotherapy
CD47/SIRPα
Crystal structure
Inhibitor
Computer-aided drug discovery
Hot spot
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021004219

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http://www.sciencedirect.com/science/article/pii/S2001037021004219

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