Sloppiness: Fundamental study, new formalism and its application in model assessment.

Computational modelling of biological processes poses multiple challenges in each stage of the modelling exercise. Some significant challenges include identifiability, precisely estimating parameters from limited data, informative experiments and anisotropic sensitivity in the parameter space. One o...

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Bibliographic Details
Main Authors: Prem Jagadeesan, Karthik Raman, Arun K Tangirala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0282609