The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection.

The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection.

Earlier studies had suggested that epigenetic mechanisms play an important role in the control of human cytomegalovirus (HCMV) infection. Here we show that productive HCMV infection is indeed under the control of histone H3K27 trimethylation. The histone H3K27 methyltransferase EZH2, and its regulat...

Full description

Bibliographic Details
Main Authors: George Sourvinos, Antigoni Morou, Ioannis Sanidas, Ignea Codruta, Scott A Ezell, Christina Doxaki, Sotirios C Kampranis, Filippos Kottakis, Philip N Tsichlis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4022736?pdf=render

Internet

http://europepmc.org/articles/PMC4022736?pdf=render

Similar Items