Age-related elevation of O-GlcNAc causes meiotic arrest in male mice

Age-related elevation of O-GlcNAc causes meiotic arrest in male mice

Abstract In recent years, the postponement of childbearing has become a critical social issue. Male fertility is negatively associated with age because of testis aging. Spermatogenesis is impaired with age, but the molecular mechanism remains unknown. The dynamic posttranslational modification O-lin...

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Bibliographic Details
Main Authors: Zhang Qian, Chuwei Li, Shanmeizi Zhao, Hong Zhang, Rujun Ma, Xie Ge, Jun Jing, Li Chen, Jinzhao Ma, Yang Yang, Lu Zheng, Kemei Zhang, Zhaowanyue He, Mengqi Xue, Ying Lin, Kadiliya Jueraitetibaike, Yuming Feng, Chun Cao, Ting Tang, Shanshan Sun, Hui Teng, Wei Zhao, Bing Yao
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01433-x

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