Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exp...

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Bibliographic Details
Main Authors: Elena Hipper, Michaela Blech, Dariush Hinderberger, Patrick Garidel, Wolfgang Kaiser
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
photo-degradation
analytical methods
post-translational modification
protein degradation
reactive oxygen species
Online Access:https://www.mdpi.com/1999-4923/14/1/72

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https://www.mdpi.com/1999-4923/14/1/72

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