Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia

Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia

The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ferredoxin reductase (PFOR) and nitroreductase (NR) 1 which metabolize metronidazol...

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Bibliographic Details
Main Authors: Christina S. Saghaug, Astrid L. Gamlem, Kirsti B. Hauge, Juha Vahokoski, Christian Klotz, Toni Aebischer, Nina Langeland, Kurt Hanevik
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Nitroreductase
Pyruvate ferredoxin oxidoreductase
Metronidazole
Genetic diversity
Allele
Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320722000367

Internet

http://www.sciencedirect.com/science/article/pii/S2211320722000367

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