Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation

Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation

Abstract Cav3.2 T-type calcium channels are important for the signaling of nociceptive information in the primary afferent pain pathway. During neuropathy and peripheral inflammation, Cav3.2 channels are upregulated due to an increased association with the deubiquitinase USP5. Disrupting these inter...

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Bibliographic Details
Main Authors: Vinicius M. Gadotti, Gerald W. Zamponi
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Brain
Subjects:
T-type calcium channel
Ubiquitination
Inflammation
Pain
Sex differences
USP5
Online Access:http://link.springer.com/article/10.1186/s13041-018-0405-4

Internet

http://link.springer.com/article/10.1186/s13041-018-0405-4

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