The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs

The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs

The NAD+-dependent protein deacetylase SIRT1 regulates energy metabolism, responses to stress, and aging by deacetylating many different proteins, including histones and transcription factors. The mechanisms controlling SIRT1 enzymatic activity are complex and incompletely characterized, yet essenti...

Full description

Bibliographic Details
Main Authors: Fiorella Ghisays, Cynthia S. Brace, Shawn M. Yackly, Hyock Joo Kwon, Kathryn F. Mills, Elena Kashentseva, Igor P. Dmitriev, David T. Curiel, Shin-ichiro Imai, Tom Ellenberger
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715001825

Internet

http://www.sciencedirect.com/science/article/pii/S2211124715001825

Similar Items