Comparative Analysis of Type 1 and Type Z Protein Phosphatases Reveals D615 as a Key Residue for Ppz1 Regulation

Comparative Analysis of Type 1 and Type Z Protein Phosphatases Reveals D615 as a Key Residue for Ppz1 Regulation

Type 1 Ser/Thr protein phosphatases are represented in all fungi by two enzymes, the ubiquitous PP1, with a conserved catalytic polypeptide (PP1c) and numerous regulatory subunits, and PPZ, with a C-terminal catalytic domain related to PP1c and a variable N-terminal extension. Current evidence indic...

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Bibliographic Details
Main Authors: Antonio Casamayor, Diego Velázquez, Carlos Santolaria, Marcel Albacar, Morten I. Rasmussen, Peter Højrup, Joaquín Ariño
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
protein phosphatase
Ppz1
PP1c
sequence comparisons
cross-linking proteomics
enzyme inhibition
Online Access:https://www.mdpi.com/1422-0067/23/3/1327

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https://www.mdpi.com/1422-0067/23/3/1327

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