Laboratory-Based Rationale for Targeting the Protein Homeostasis Network in AL Amyloidosis

Laboratory-Based Rationale for Targeting the Protein Homeostasis Network in AL Amyloidosis

AL amyloidosis is an incurable plasma cell dyscrasia with limited therapeutic options. The pathogenetic mechanism in AL amyloidosis is the deposition of insoluble fibrillary aggregates of misfolded immunoglobulin (Ig) free light chains (FLC) and chaperone proteins in target organs. Therefore, AL amy...

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Bibliographic Details
Main Authors: Giada Bianchi, Maria Moscvin, Raymond L. Comenzo
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Hemato
Subjects:
AL amyloidosis
proteostasis network
ubiquitin–proteasome system
therapeutic targets
proteotoxicity
protein degradation
Online Access:https://www.mdpi.com/2673-6357/3/2/22

Internet

https://www.mdpi.com/2673-6357/3/2/22

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