Laboratory-Based Rationale for Targeting the Protein Homeostasis Network in AL Amyloidosis
AL amyloidosis is an incurable plasma cell dyscrasia with limited therapeutic options. The pathogenetic mechanism in AL amyloidosis is the deposition of insoluble fibrillary aggregates of misfolded immunoglobulin (Ig) free light chains (FLC) and chaperone proteins in target organs. Therefore, AL amy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
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| Series: | Hemato |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-6357/3/2/22 |