Laboratory-Based Rationale for Targeting the Protein Homeostasis Network in AL Amyloidosis
AL amyloidosis is an incurable plasma cell dyscrasia with limited therapeutic options. The pathogenetic mechanism in AL amyloidosis is the deposition of insoluble fibrillary aggregates of misfolded immunoglobulin (Ig) free light chains (FLC) and chaperone proteins in target organs. Therefore, AL amy...
Main Authors: | Giada Bianchi, Maria Moscvin, Raymond L. Comenzo |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-04-01
|
Series: | Hemato |
Subjects: | |
Online Access: | https://www.mdpi.com/2673-6357/3/2/22 |
Similar Items
-
Mechanisms of Organ Damage and Novel Treatment Targets in AL Amyloidosis
by: Francesca Lavatelli
Published: (2022-01-01) -
On the Role of the Immunoproteasome in Protein Homeostasis
by: Michael Basler, et al.
Published: (2021-11-01) -
Gatekeepers of the Gut: The Roles of Proteasomes at the Gastrointestinal Barrier
by: Gayatree Mohapatra, et al.
Published: (2021-07-01) -
Degradation of Intrinsically Disordered Proteins by the NADH 26S Proteasome
by: Peter Tsvetkov, et al.
Published: (2020-12-01) -
Generalizable Compositional Features Influencing the Proteostatic Fates of Polar Low-Complexity Domains
by: Sean M. Cascarina, et al.
Published: (2021-08-01)