Antagonism of regulatory ISGs enhances the anti-melanoma efficacy of STING agonists

Antagonism of regulatory ISGs enhances the anti-melanoma efficacy of STING agonists

BackgroundStimulator of Interferon Genes (STING) is a dsDNA sensor that triggers type I inflammatory responses. Recent data from our group and others support the therapeutic efficacy of STING agonists applied intratumorally or systemically in a range of murine tumor models, with treatment benefits a...

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Bibliographic Details
Main Authors: Jessica N. Filderman, Jennifer L. Taylor, Jianmin Wang, Yali Zhang, Prashant Singh, Mark A. Ross, Simon C. Watkins, Ayah Nedal Al Bzour, Lilit Karapetyan, Pawel Kalinski, Walter J. Storkus
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
ARG2
combination immunotherapy
COX2
immune checkpoint
ISG15
melanoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1334769/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1334769/full

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