Repositioning Quinacrine Toward Treatment of Ovarian Cancer by Rational Combination With TRAIL

Repositioning Quinacrine Toward Treatment of Ovarian Cancer by Rational Combination With TRAIL

Quinacrine has been identified as a potent DR5-inducing agent that sensitizes cancer cells to TRAIL-induced apoptosis. In the current study, we found that quinacrine increased DR5 mRNA levels significantly in ovarian cancer cell lines regardless of p53 status. Further study showed the half-life of D...

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Bibliographic Details
Main Authors: Rui Liang, Yuanfei Yao, Guangyu Wang, Er Yue, Guangchao Yang, Xiuying Qi, Yang Wang, Ling Zhao, Tongsen Zheng, Yanqiao Zhang, Edward Wenge Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
quinacrine
TRAIL (TNF-related apoptosis-inducing Ligand/Apo2L)
DR5
ovarian cancer
lysosomal permeabilization
intraperitoneal (IP)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01118/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01118/full

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