Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches
Asparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies. These modifications can pose a significant challenge in the development of biopharmaceuticals. As such, the early engineering and selection of chemi...
| Главные авторы: | , , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Taylor & Francis Group
2024-12-01
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| Серии: | mAbs |
| Предметы: | |
| Online-ссылка: | https://www.tandfonline.com/doi/10.1080/19420862.2024.2333436 |