Structural Elucidation of the DFG-Asp in and DFG-Asp out States of TAM Kinases and Insight into the Selectivity of Their Inhibitors

Structural Elucidation of the DFG-Asp in and DFG-Asp out States of TAM Kinases and Insight into the Selectivity of Their Inhibitors

Structural elucidation of the active (DFG-Asp in) and inactive (DFG-Asp out) states of the TAM family of receptor tyrosine kinases is required for future development of TAM inhibitors as drugs. Herein we report a computational study on each of the three TAM members Tyro-3, Axl and Mer. DFG-Asp in an...

ver descrição completa

Detalhes bibliográficos
Principais autores: Abdellah Messoussi, Lucile Peyronnet, Clémence Feneyrolles, Gwénaël Chevé, Khalid Bougrin, Aziz Yasri
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2014-10-01
coleção:Molecules
Assuntos:
tyrosine kinase
TAM kinase family
homology model
kinase selectivity
Acesso em linha:http://www.mdpi.com/1420-3049/19/10/16223

Internet

http://www.mdpi.com/1420-3049/19/10/16223

Registros relacionados