Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis

Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis

Abstract Posterior fossa group A ependymomas (EPN_PFA) are characterized by a loss of H3 K27 trimethylation due to either EZHIP overexpression or H3 p.K27M mutation, similar to H3 K27-altered diffuse midline gliomas (DMG), but in reverse proportions. Very little data is available in the literature c...

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Bibliographic Details
Main Authors: Cassandra Mariet, David Castel, Jacques Grill, Raphaël Saffroy, Volodia Dangouloff-Ros, Nathalie Boddaert, Francisco Llamas-Guttierrez, Céline Chappé, Stéphanie Puget, Lauren Hasty, Fabrice Chrétien, Alice Métais, Pascale Varlet, Arnault Tauziède-Espariat
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Acta Neuropathologica Communications
Subjects:
Posterior fossa
Ependymoma
Histones
DNA-methylation
Online Access:https://doi.org/10.1186/s40478-022-01442-4

Internet

https://doi.org/10.1186/s40478-022-01442-4

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