Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML

Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML

In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to drug resistance. Candidate drug discovery in AML requ...

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Bibliographic Details
Main Authors: Jenna R. James, Johnathan Curd, Jennifer C. Ashworth, Mays Abuhantash, Martin Grundy, Claire H. Seedhouse, Kenton P. Arkill, Amanda J. Wright, Catherine L. R. Merry, Alexander Thompson
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
acute myeloid leukemia
3D peptide hydrogel model
candidate drugs
Online Access:https://www.mdpi.com/1422-0067/24/4/4235

Internet

https://www.mdpi.com/1422-0067/24/4/4235

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