Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice

Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment and no cure. Mutations in profilin 1 were identified as a cause of familial ALS (fALS) in 2012. We investigated the functional impact of mutant profilin 1 expression in spinal cords during mouse dev...

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Bibliographic Details
Main Authors: Merryn Brettle, Holly Stefen, Aleksandra Djordjevic, Sandra Y. Y. Fok, Josephine W. Chan, Annika van Hummel, Julia van der Hoven, Magdalena Przybyla, Alexander Volkerling, Yazi D. Ke, Fabien Delerue, Lars M. Ittner, Thomas Fath
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
profilin 1
amyotrophic lateral sclerosis
actin
neurodegeneration
motor neurons
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00231/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00231/full

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