IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury

IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury

Abstract Background Survival and therapeutic actions of bone marrow-derived mesenchymal stem cells (BMMSCs) can be limited by the hostile microenvironment present during acute spinal cord injury (SCI). Here, we investigated whether BMMSCs overexpressing insulin-like growth factor 1 (IGF-1), a cytoki...

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Príomhchruthaitheoirí: Kyan James Allahdadi, Thaís Alves de Santana, Girlaine Café Santos, Carine Machado Azevedo, Roberta Alves Mota, Carolina Kymie Nonaka, Daniela Nascimento Silva, Clarissa Xavier Resende Valim, Cláudio Pereira Figueira, Washington Luis Conrado dos Santos, Renan Fernandes do Espirito Santo, Afrânio Ferreira Evangelista, Cristiane Flora Villarreal, Ricardo Ribeiro dos Santos, Bruno Solano Freitas de Souza, Milena Botelho Pereira Soares
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: BMC 2019-05-01
Sraith:Stem Cell Research & Therapy
Ábhair:
Spinal cord injury
Bone marrow-derived mesenchymal stem cells
IGF-1
Gene and cell therapy
Rochtain ar líne:http://link.springer.com/article/10.1186/s13287-019-1223-z

Ar líne

http://link.springer.com/article/10.1186/s13287-019-1223-z

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