Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health

Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health

Abstract Background Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typically derived via penalised regression, whereby a linear weighted sum of DN...

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Bibliographic Details
Main Authors: Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio-Gómez, Danni A. Gadd, Robert F. Hillary, Aleksandra D. Chybowska, Daniel L. McCartney, Archie Campbell, Paul Redmond, Danielle Page, Adele Taylor, Janie Corley, Sarah E. Harris, Maria Valdés Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary, James P. Boardman, Donncha S. Mullin, Tom C. Russ, Simon R. Cox, Riccardo E. Marioni
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Epigenetic scores
General cognitive function
Brain imaging
Dementia
Blood-based biomarkers
Online Access:https://doi.org/10.1186/s13148-024-01661-7

Internet

https://doi.org/10.1186/s13148-024-01661-7

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