M2 macrophage polarization in systemic sclerosis fibrosis: pathogenic mechanisms and therapeutic effects

M2 macrophage polarization in systemic sclerosis fibrosis: pathogenic mechanisms and therapeutic effects

Systemic sclerosis (SSc, scleroderma), is an autoimmune rheumatic disease characterized by fibrosis of the skin and internal organs, and vasculopathy. Preventing fibrosis by targeting aberrant immune cells that drive extracellular matrix (ECM) over-deposition is a promising therapeutic strategy for...

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Bibliographic Details
Main Authors: Mingyue Hu, Zhongliu Yao, Li Xu, Muzi Peng, Guiming Deng, Liang Liu, Xueyu Jiang, Xiong Cai
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Heliyon
Subjects:
Systemic sclerosis
Fibrosis
M2 macrophage polarization
Fibroblasts
Myofibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023034138

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http://www.sciencedirect.com/science/article/pii/S2405844023034138

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