ROS-Dependent ER Stress and Autophagy Mediate the Anti-Tumor Effects of Tributyltin (IV) Ferulate in Colon Cancer Cells

ROS-Dependent ER Stress and Autophagy Mediate the Anti-Tumor Effects of Tributyltin (IV) Ferulate in Colon Cancer Cells

Organotin compounds represent potential cancer therapeutics due to their pro-apoptotic action. We recently synthesized the novel organotin ferulic acid derivative tributyltin (IV) ferulate (TBT-F) and demonstrated that it displays anti-tumor properties in colon cancer cells related with autophagic c...

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Bibliographic Details
Main Authors: Adriana Celesia, Ornella Morana, Tiziana Fiore, Claudia Pellerito, Antonella D’Anneo, Marianna Lauricella, Daniela Carlisi, Anna De Blasio, Giuseppe Calvaruso, Michela Giuliano, Sonia Emanuele
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
tributyltin (IV) derivative
ROS
oxidative stress
endoplasmic reticulum stress
autophagic cell death
Online Access:https://www.mdpi.com/1422-0067/21/21/8135

Internet

https://www.mdpi.com/1422-0067/21/21/8135

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