TMEM219 regulates the transcription factor expression and proliferation of beta cells

TMEM219 regulates the transcription factor expression and proliferation of beta cells

Pancreatic beta cells replenishment is considered the next therapeutic option for type 1 diabetes; while stimulating endogenous beta cells proliferation is the “holy grail” for those patients with exhausted beta cell mass. Here we are demonstrating that the pro-apoptotic receptor TMEM219 is expresse...

Full description

Bibliographic Details
Main Authors: Francesca D’Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Paolo Fiorina
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Endocrinology
Subjects:
type 1 diabetes
endocrine progenitors
TMEM219
IGFBP3
islets
mature and immature beta cells
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1306127/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2024.1306127/full

Similar Items