Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy

Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy

In acute sympathetic stress, catecholamine overload can lead to stress cardiomyopathy. We tested the hypothesis that cardiomyocyte NOX4 (NADPH oxidase 4)-dependent mitochondrial oxidative stress mediates inflammation and diastolic dysfunction in stress cardiomyopathy. Isoproterenol (ISO; 5 mg/kg) in...

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Bibliographic Details
Main Authors: Aleksandr E. Vendrov, Han Xiao, Andrey Lozhkin, Takayuki Hayami, Guomin Hu, Matthew J. Brody, Junichi Sadoshima, You-Yi Zhang, Marschall S. Runge, Nageswara R. Madamanchi
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Redox Biology
Subjects:
Cardiomyopathy
Cardiomyocyte mitochondria
Resident macrophages
Cardiac fibroblasts
NADPH oxidase 4
Diastolic dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723003385

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http://www.sciencedirect.com/science/article/pii/S2213231723003385

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