Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis

Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis

NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses autoimmunity by facilitating dead cell clearance via LC3-associated phagocytosis (LAP). The absence of LAP reportedly causes an autoinflammato...

Full description

Bibliographic Details
Main Authors: Rachael A. Gordon, Christina Giannouli, Chirag Raparia, Sheldon I. Bastacky, Anthony Marinov, William Hawse, Richard Cattley, Jeremy S. Tilstra, Allison M. Campbell, Kevin M. Nickerson, Anne Davidson, Mark J. Shlomchik
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-04-01
Series:JCI Insight
Subjects:
Autoimmunity
Online Access:https://doi.org/10.1172/jci.insight.155537

Internet

https://doi.org/10.1172/jci.insight.155537

Similar Items