Polydatin protects against acute cholestatic liver injury in mice via the inhibition of oxidative stress and endoplasmic reticulum stress

Polydatin protects against acute cholestatic liver injury in mice via the inhibition of oxidative stress and endoplasmic reticulum stress

Cholestatic liver injury is a chronic disease caused by the retention of toxic hydrophobic bile salts in the liver, but lack of efficient therapy. Here, we identified that polydatin (PD), a natural precursor of resveratrol (RES), has potent detoxification effects on cholestatic liver injury. PD inhi...

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Bibliographic Details
Main Authors: Jinan Fang, Lingling Luo, Zunli Ke, Chuhe Liu, Liufang Yin, Yin Yao, Qin Feng, Cheng Huang, Peiyong Zheng, Shengjie Fan
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Journal of Functional Foods
Subjects:
Polydatin
Cholestasis
Oxidative stress
Endoplasmic reticulum stress
CHOP
Online Access:http://www.sciencedirect.com/science/article/pii/S175646461930091X

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http://www.sciencedirect.com/science/article/pii/S175646461930091X

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