BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells.

BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells.

ATP-binding-cassette family membrane proteins play an important role in multidrug resistance. In this study, we investigated BIRB796, an orally active inhibitor of p38 mitogen-activated protein kinase, reversed MDR induced by ABCB1, ABCG2 and ABCC1. Our results showed that BIRB796 could reverse ABCB...

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Bibliographic Details
Main Authors: Dan He, Xiao-qin Zhao, Xing-gui Chen, Yi Fang, Satyakam Singh, Tanaji T Talele, Hui-juan Qiu, Yong-ju Liang, Xiao-kun Wang, Guo-qing Zhang, Zhe-sheng Chen, Li-wu Fu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3548808?pdf=render

Internet

http://europepmc.org/articles/PMC3548808?pdf=render

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