Hypochlorous acid-modified human serum albumin suppresses MHC class II - dependent antigen presentation in pro-inflammatory macrophages

Hypochlorous acid-modified human serum albumin suppresses MHC class II - dependent antigen presentation in pro-inflammatory macrophages

Macrophages are innate immune cells that internalize and present exogenous antigens to T cells via MHC class II proteins. They operate at sites of infection in a highly inflammatory environment, generated in part by reactive oxygen species, in particular the strong oxidant hypochlorous acid (HOCl) p...

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Bibliographic Details
Main Authors: Agnes Ulfig, Verian Bader, Marharyta Varatnitskaya, Natalie Lupilov, Konstanze F. Winklhofer, Lars I. Leichert
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Redox Biology
Subjects:
Macrophages
Antigen presenting cells
Hypochlorous acid
N-chlorination
MHC II
CD36
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001294

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http://www.sciencedirect.com/science/article/pii/S2213231721001294

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