Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination

Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination

Canavan disease (CD) is a neurodegenerative disease, caused by a deficiency in the enzyme aspartoacylase (ASPA). This enzyme has been localized to oligodendrocytes; however, it is still undefined how ASPA deficiency affects oligodendrocyte development. In normal mice the pattern of ASPA expression c...

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Bibliographic Details
Main Authors: Natalia S. Mattan, Cristina A. Ghiani, Marcia Lloyd, Reuben Matalon, Dean Bok, Patrizia Casaccia, Jean de Vellis
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Neurobiology of Disease
Subjects:
Oligodendrocytes
Neural cells
Development
Canavan disease
Aspartoacylase
Leukodystrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002275

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http://www.sciencedirect.com/science/article/pii/S0969996110002275

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