Using in vitro data to derive acceptable exposure levels: A case study on PBDE developmental neurotoxicity

Using in vitro data to derive acceptable exposure levels: A case study on PBDE developmental neurotoxicity

Background: Current acceptable chemical exposure levels (e.g., tolerable daily intake) are mainly based on animal experiments, which are costly, time-consuming, considered non-ethical by many, and may poorly predict adverse outcomes in humans. Objective: To evaluate a method using human in vitro dat...

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Bibliographic Details
Main Authors: Sherri Bloch, Laura Lévêque, Irva Hertz-Picciotto, Birgit Puschner, Ellen Fritsche, Jördis Klose, Nynke I. Kramer, Maryse F. Bouchard, P. Charukeshi Chandrasekera, Marc-André Verner
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Environment International
Subjects:
Risk assessment
In vitro toxicology testing
Mass-balance modeling
Pharmacokinetic modeling
Tolerable daily intake
Biomonitoring equivalent
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412023006840

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http://www.sciencedirect.com/science/article/pii/S0160412023006840

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