Vitamin B12 insufficiency in excess folic acid downregulates methylenetetrahydrofolate reductase gene and increases homocysteine, tumor necrosis factor-alpha, and oxidative stress in hepatocytes

Vitamin B12 insufficiency in excess folic acid downregulates methylenetetrahydrofolate reductase gene and increases homocysteine, tumor necrosis factor-alpha, and oxidative stress in hepatocytes

OBJECTIVE: Folate and Vitamin B12 (B12) are crucial for normal growth, development, and cellular functions. The aim of this study was to determine the effect of required and excess folic acid (FA) concentration and imbalance of FA and B12 caused due to folate fortification on hepatocytes health and...

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Bibliographic Details
Main Authors: Tejas Shah, Kalpana Joshi, Sanjay Mishra
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Indian Journal of Health Sciences and Biomedical Research KLEU
Subjects:
Folate
homocysteine
human hepatocellular carcinoma
methylenetetrahydrofolate reductase
tumor necrosis factor-alpha
Vitamin B12
Online Access:http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2018;volume=11;issue=1;spage=12;epage=18;aulast=Shah

Internet

http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2018;volume=11;issue=1;spage=12;epage=18;aulast=Shah

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