Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption

Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption

Healthy bone remodeling results from a balanced bone formation and bone resorption realized by bone-forming osteoblasts and bone-resorbing osteoclasts, respectively. Recently, Thy-1 (CD90) was identified as positive regulator of osteoblast differentiation and activation, thus, promoting bone formati...

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Bibliographic Details
Main Authors: Ann-Kristin Picke, Graeme M. Campbell, Felix N. Schmidt, Björn Busse, Martina Rauner, Jan C. Simon, Ulf Anderegg, Lorenz C. Hofbauer, Anja Saalbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
obesity
Thy-1
bone mass
osteoblast
osteoclast
adipocytes
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00127/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2018.00127/full

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