Sleep need driven oscillation of glutamate synaptic phenotype

Sleep need driven oscillation of glutamate synaptic phenotype

Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report an increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2–3. Silent synapses are absent, decreasing the plastic potential to co...

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Bibliographic Details
Main Authors: Kaspar E Vogt, Ashwinikumar Kulkarni, Richa Pandey, Mantre Dehnad, Genevieve Konopka, Robert W Greene
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
sleep
transcriptome
synapse
AMPA/NMDA ratio
sleep homeostasis
MEF2c
Online Access:https://elifesciences.org/articles/98280

Internet

https://elifesciences.org/articles/98280

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