Effects of biomechanical and biochemical stimuli on angio- and vasculogenesis in a complex microvasculature-on-chip

Summary: The endothelium of blood vessels is a vital organ that reacts differently to subtle changes in stiffness and mechanical forces exerted on its environment (extracellular matrix (ECM)). Upon alteration of these biomechanical cues, endothelial cells initiate signaling pathways that govern vasc...

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Bibliographic Details
Main Authors: Dario Ferrari, Arunima Sengupta, Lyong Heo, Laszlo Pethö, Johann Michler, Thomas Geiser, Vinicio A. de Jesus Perez, Wolfgang M. Kuebler, Soheila Zeinali, Olivier T. Guenat
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223002754