TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

Aberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, thus impacting inflammation-induced colon cancer dev...

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Bibliographic Details
Main Authors: Hong-Xia Zhang, Zhi-Sheng Xu, Hen Lin, Mi Li, Tian Xia, Kaisa Cui, Su-Yun Wang, Youjun Li, Hong-Bing Shu, Yan-Yi Wang
Format: Article
Language:English
Published: Nature Portfolio 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05796-z

Internet

https://doi.org/10.1038/s41467-018-05796-z

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