DREADD activation of the lateral orbitofrontal increases cocaine-taking and cocaine-seeking in male and female rats during intermittent access self-administration under risky conditions

Addiction is a disorder that can be characterized in part as the constant pursuit of a particular substance despite negative consequences. Although the orbitofrontal cortex (OFC) is known to regulate risk-taking more generally and be critical to the development of addiction, its role in regulating d...

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Bibliographic Details
Main Authors: Zackari D. Murphy, Ruth Mulugeta, Alex Tran, Susan M. Ferguson
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Addiction Neuroscience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2772392523000652